Synthesis, antitubercular and antimicrobial activities of some new pyrazoline and isoxazole derivatives

被引：0
|
作者：
Vyas, D. H. [1 ]
Tala, S. D. [1 ]
Dhaduk, M. F. [1 ]
Akbari, J. D. [1 ]
Joshi, H. S. [1 ]
机构：
[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2007年 / 84卷 / 11期
关键词：
pyrazolines; isoxazoles; microbial activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cyclocondensation of hydrazine hydrate with (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones (1a-j) in glacial acetic acid afford corresponding 1-acetyl-3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-4,5-dihydro-1H-pyrazoles (2a-j). While the compounds 1a-j on reaction with hydroxylamine hydrochloride in presence of acetic acid and sodium acetate to give 3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-isoxazoles (3a-j). All the compounds were tested against different microbes for their antimicrobial activity and compounds 2a-j were tested for antitubercular activity.
引用
收藏
页码：1140 / 1144
页数：5
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