MetaADEDB 2.0: a comprehensive database on adverse drug events

被引：9

作者：

Yu, Zhuohang ^{[1
]}

Wu, Zengrui ^{[1
]}

Li, Weihua ^{[1
]}

Liu, Guixia ^{[1
]}

Tang, Yun ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

来源：

BIOINFORMATICS | 2021年 / 37卷 / 15期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

D O I：

10.1093/bioinformatics/btaa973

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

MetaADEDB is an online database we developed to integrate comprehensive information on adverse drug events (ADEs). The first version of MetaADEDB was released in 2013 and has been widely used by researchers. However, it has not been updated for more than seven years. Here, we reported its second version by collecting more and newer data from the U.S. FDA Adverse Event Reporting System (FAERS) and Canada Vigilance Adverse Reaction Online Database, in addition to the original three sources. The new version consists of 744 709 drug-ADE associations between 8498 drugs and 13 193 ADEs, which has an over 40% increase in drug-ADE associations compared to the previous version. Meanwhile, we developed a new and user-friendly web interface for data search and analysis. We hope that MetaADEDB 2.0 could provide a useful tool for drug safety assessment and related studies in drug discovery and development.

引用

页码：2221 / 2222

页数：2

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