Design and Synthesis of Novel Dinucleotide Analogs

被引：0

作者：

Valiyev, F. ^{[1
,3
]}

Abbasov, V. ^{[3
]}

Liu, H. J. ^{[1
,2
]}

Tsai, F. Y. ^{[4
]}

机构：

[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

[3] Azerbaijan NAS, Inst Petrochem Proc, Baku, Azerbaijan

[4] Chang Gung Univ, Ctr Gen Educ, Tao Tuan 333, Taiwan

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2010年 / 7卷 / 03期

关键词：

Nucleosides; Dinucleotides; Antivirals; Anti-HIV; Phosphorotriesters; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV INTEGRASE; ANTIVIRAL ACTIVITY; CHEMOTHERAPY; RECOGNITION; INHIBITION; ABACAVIR; TYPE-1; RNA;

D O I：

10.1007/BF03246046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses of dinucleotide analogs, (S,R) cis-(4-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-dioxolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5a) and (S,R) cis-(5-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-oxathiolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5b), were accomplished by the use of a new strategy. The use of phenyldichlorophosphate (Method A) as the coupling reagent was shown to possess superiority relative to the reported use of di(1H-benzo[d][1,2,3]triazol-1-yl)phenyl phosphonate (Method B).

引用

页码：597 / 602

页数：6

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