Poly(cytidylic acid) and poly(adenylic acid) analogues: synthesis and catalytic activity for hydrolysis of dinucleotides and nucleic acids

被引：4
|
作者：
Han, MJ
Kim, YH
Yoo, KS
Son, SW
Kang, YG
Chang, JY [1 ]
机构：
[1] Ajou Univ, Dept Mol Sci & Technol, Suwon 442749, South Korea
[2] Seoul Natl Univ, Sch Mat Sci & Engn, Hyperstruct Organ Mat Res Ctr, Kwanak Ku, Seoul 151744, South Korea
来源：
POLYMER | 2003年 / 44卷 / 21期
关键词：
cyclocopolymerization; synthetic enzyme; polynucleotide analogue;
D O I：
10.1016/S0032-3861(03)00731-6
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Poly(cytidylic acid) and poly(adenylic acid) analogues, resembling closely the structures of the natural polymers, were synthesized by the alternating cyclocopolymerization of a nucleoside derivative and acrylic anhydride, and subsequent hydrolysis. The polymers catalyzed the cleavage of dinuleotides and nucleic acids (DNA and RNA). Poly(cytidylic acid) and poly(adenylic acid) analogues accelerated the hydrolysis of GpG and TpT, respectively, faster than other dinucleotides due to the base pairing. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：6475 / 6482
页数：8
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