Two new triterpenoids from the fruits of Aphanamixis polystachya

被引：8
|
作者：
Wu, Shi-Li [1 ,2 ]
Zou, Qiu-Ping [1 ,2 ]
Xie, Xiao-Yan [1 ,2 ]
Ren, Jia-Jia [1 ,2 ]
Fan, Zhang [1 ,2 ]
OuYang, Jing-Rong [1 ,2 ]
Yin, Peng-Cheng [1 ,2 ]
Dong, Fa-Wu [1 ,2 ]
He, Hong-Ping [1 ,2 ]
机构：
[1] Yunnan Univ Chinese Med, Yunnan Key Lab Southen Med Utilizat, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Univ Chinese Med, Coll Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Meliaceae; Aphanamixis polystachya; triucallane triterpenoids; cytotoxicity; LIMONOIDS;
D O I：
10.1080/10286020.2021.1972980
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new triucallane triterpenoids, polystanin F (1) and polystanin G (2), along with eight known compounds (3-10) were isolated from the fruits of Aphanamixis polystachya. Their structures were established on the basis of extensive spectroscopic analysis. Moreover, eight compounds were evaluated for their in vitro cytotoxicity against three cancer cell lines (liver cancer RT112, colon cancer HCT-116 and breast cancer M231) using the MTT method. Compound 7 showed significant cytotoxic activity against HCT-116 with IC50 1.27 mu M.
引用
收藏
页码：738 / 745
页数：8
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