Th1/Th2 balance in preeclampsia

被引：250
|
作者：
Saito, S [1 ]
Sakai, M [1 ]
机构：
[1] Toyama Med & Pharmaceut Univ, Dept Obstet & Gynecol, Toyama 9300194, Japan
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2003年 / 59卷 / 02期
关键词：
etiology; IL-12; inflammation; preeclampsia; Th1;
D O I：
10.1016/S0165-0378(03)00045-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system allowing the second physiological trophoblastic invasion. In this review, we discuss that Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：161 / 173
页数：13
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