Epidemiological trends of tetanus from East Delhi, India: A hospital-based study

被引:9
|
作者
Narang, Manish
Khurana, Aman
Gomber, Sunil
Choudhary, Nidhi
机构
[1] Univ Delhi, Dept Pediat, Univ Coll Med Sci, Delhi 110007, India
[2] Univ Delhi, Guru Teg Bahadur Hosp, Delhi 110007, India
关键词
Tetanus; Immunoglobulin; Elimination; NEONATAL TETANUS;
D O I
10.1016/j.jiph.2013.07.006
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: To study the demographic profile, prognostic indicators, and mortality of tetanus patients and treatment outcomes following intramuscular anti-tetanus immunoglobulin (ATG) alone or combined intrathecal and intramuscular ATG. Design: Retrospective study. Setting: Inpatients from a tertiary care hospital. Subjects: One hundred children under 12 years of age diagnosed with tetanus and admitted from January 2003 to December 2007 were included in the study. Methods: Case records of patients with neonatal tetanus (n=30) and post-neonatal tetanus (n = 70) were evaluated retrospectively. The diagnosis of tetanus was based on World Health Organization (WHO) criteria. The outcomes of patients treated with either intramuscular ATG or both intrathecal and intramuscular ATG were separately compared in the neonatal and post-neonatal groups. Results: Our study revealed difficulty in feeding, trismus, spasms, rigidity, and opisthotonus posturing as the predominant clinical manifestations. The survival rate for children receiving tetanus immunoglobulin by the dual route was significantly higher than for children receiving the immunoglobulin via the intramuscular route. Seizures and tremors were poor prognostic factors associated with tetanus. (C) 2013 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:121 / 124
页数:4
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