Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

被引：65
|
作者：
Sureram, Sanya [1 ]
Senadeera, Sarath P. D. [2 ]
Hongmanee, Poonpilas [3 ]
Mahidol, Chulabhorn [1 ,2 ]
Ruchirawat, Somsak [1 ,2 ,4 ]
Kittakoop, Prasat [1 ,2 ,4 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Chulabhorn Grad Inst, Chem Biol Program, Bangkok 10210, Thailand
[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Microbiol,Dept Pathol, Bangkok 10400, Thailand
[4] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol, Bangkok, Thailand
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期
关键词：
Antimycobacterial activity; Multidrug-resistant tuberculosis; Alkaloids; Tiliacora triandra; Mycobacterium tuberculosis; ASSAY; EPIDEMIOLOGY; RESPONSES; RACEMOSA; ROOTS;
D O I：
10.1016/j.bmcl.2012.02.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 mu g/ml, but they exhibited the MIC value at 3.1 mu g/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2902 / 2905
页数：4
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