Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

被引：65
|
作者：
Sureram, Sanya [1 ]
Senadeera, Sarath P. D. [2 ]
Hongmanee, Poonpilas [3 ]
Mahidol, Chulabhorn [1 ,2 ]
Ruchirawat, Somsak [1 ,2 ,4 ]
Kittakoop, Prasat [1 ,2 ,4 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Chulabhorn Grad Inst, Chem Biol Program, Bangkok 10210, Thailand
[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Microbiol,Dept Pathol, Bangkok 10400, Thailand
[4] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol, Bangkok, Thailand
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期
关键词：
Antimycobacterial activity; Multidrug-resistant tuberculosis; Alkaloids; Tiliacora triandra; Mycobacterium tuberculosis; ASSAY; EPIDEMIOLOGY; RESPONSES; RACEMOSA; ROOTS;
D O I：
10.1016/j.bmcl.2012.02.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 mu g/ml, but they exhibited the MIC value at 3.1 mu g/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2902 / 2905
页数：4
相关论文
共 50 条
  • [1] Antimycobacterial activity of econazole against multidrug-resistant strains of Mycobacterium tuberculosis
    Ahmad, Zahoor
    Sharma, Sadhna
    Khuller, G. K.
    Singh, Pushpendra
    Faujdar, Jaya
    Katoch, V. M.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2006, 28 (06) : 543 - 544
  • [2] NEW BISBENZYLISOQUINOLINE ALKALOIDS FROM TILIACORA-TRIANDRA
    PACHALY, P
    KHOSRAVIAN, H
    [J]. PLANTA MEDICA, 1988, (05) : 433 - 437
  • [3] In vitro activity of linezolid against multidrug-resistant Mycobacterium tuberculosis isolates
    Erturan, Z
    Uzun, M
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2005, 26 (01) : 78 - 80
  • [4] Antimycobacterial activity of linezolid against multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis in Iran
    Kazemian, Hossein
    Haeili, Mehri
    Yamchi, Jalil Kardan
    Rezaei, Faranak
    Feyisa, Seifu Gizaw
    Zahednamazi, Fatemeh
    Mohajeri, Parviz
    Bostanabd, Saeed Zaker
    Shahraki, Abdolrazagh Hashemi
    Fooladi, Abbas Ali Imani
    Feizabadi, Mohammad Mehdi
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2015, 45 (06) : 668 - 670
  • [5] In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates
    Tato, M.
    de la Pedrosa, E. Gomez-G.
    Canton, R.
    Gomez-Garcia, I.
    Fortun, J.
    Martin-Davila, P.
    Baquero, F.
    Gomez-Mampaso, E.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2006, 28 (01) : 75 - 78
  • [6] In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates
    Zhang, Dan
    Wang, Yufeng
    Lu, Jie
    Pang, Yu
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (01) : 393 - 399
  • [7] Spoligotyping of multidrug-resistant Mycobacterium tuberculosis isolates in Ethiopia
    Diriba, B.
    Berkessa, T.
    Mamo, G.
    Tedla, Y.
    Ameni, G.
    [J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2013, 17 (02) : 246 - 250
  • [8] Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Isolates from China
    Zhao, Li-Li
    Chen, Yan
    Liu, Hai-Can
    Xia, Qiang
    Wu, Xiao-Cui
    Sun, Qing
    Zhao, Xiu-Qin
    Li, Gui-Lian
    Liu, Zhi-Guang
    Wan, Kang-Lin
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (04) : 1997 - 2005
  • [9] Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis
    Manuel Navarro-Garcia, Victor
    Luna-Herrera, Julieta
    Gabriela Rojas-Bribiesca, Ma
    Alvarez-Fitz, Patricia
    Yolanda Rios, Maria
    [J]. MOLECULES, 2011, 16 (09): : 7357 - 7364
  • [10] Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis
    Bettencourt, MV
    Bosne-David, S
    Amaral, L
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (01) : 69 - 71
12345