Oxidative stress and uremia

被引：21

作者：

Floccari, F ^{[1
]}

Aloisi, C ^{[1
]}

Crasci, E ^{[1
]}

Sofi, T ^{[1
]}

Campo, S ^{[1
]}

Tripodo, D ^{[1
]}

Criseo, M ^{[1
]}

Frisina, N ^{[1
]}

Buemi, M ^{[1
]}

机构：

[1] Univ Messina, Dept Internal Med, I-98100 Messina, Italy

来源：

MEDICINAL RESEARCH REVIEWS | 2005年 / 25卷 / 04期

关键词：

oxidative stress; uremia; hemodialysis; kidney transplant; AGE; AOPP;

D O I：

10.1002/med.20028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxidative stress is a pathogenic element of great importance in uremic patients, with a great impact on their survival. The cause of oxidative stress in patients on hemodialysis is traditionally attributed to the recurrent activation of polymorphonucleate neutrophils and monocytes. The effects of oxidative stress are evident on all biochemical components of biological tissues: lipids, proteins, carbohydrates, and nucleic acids. This study briefly reviews the effects of different dialytic techniques and of kidney transplant on several parameters of oxidative stress. Many different modalities of pharmaceutical intervention are then analyzed, and the clinical evidences reported. (c) 2005 Wiley Periodicals, Inc.

引用

页码：473 / 486

页数：14

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