CpG oligodeoxynucleotides containing GACGTT motifs enhance the immune responses elicited by a goose parvovirus vaccine in ducks

被引：30
|
作者：
Lee, Jai-Wei [1 ]
Lin, Yu-Ming [2 ]
Yen, Ting-Ying [2 ]
Yang, Wen-Jen [3 ]
Chu, Chun-Yen [2 ]
机构：
[1] Natl Pingtung Univ Sci & Technol, Dept Trop Agr & Int Cooperat, Pingtung 91201, Taiwan
[2] Natl Pingtung Univ Sci & Technol, Grad Inst Anim Vaccine Technol, Pingtung 91201, Taiwan
[3] Natl Univ Kaohsiung, Inst Biotechnol, Kaohsiung 811, Taiwan
来源：
VACCINE | 2010年 / 28卷 / 50期
关键词：
Adjuvant; CpG; Duck; Parvovirus; Recombinant; Vaccine; BACULOVIRUS EXPRESSION SYSTEM; IN-VITRO; CELLS; DNA; HEPATITIS; INFECTION; DUCKLINGS; ADJUVANTS; ORIGIN;
D O I：
10.1016/j.vaccine.2010.09.072
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recombinant parvovirus VP2 (rVP2) was formulated with different types of adjuvant, including aluminum adjuvant and CpG oligodeoxynucleotides (ODNs), and the immunological responses after vaccination in ducks were examined. In comparison with the control group, production of rVP2-specific antibodies, expression of cytokines in peripheral blood mononuclear cells (PBMC) stimulated by rVP2, and percentage of CD4(+)/CD8(+) cells in PBMC were significantly increased in ducks immunized with rVP2 formulated with CpG ODNs containing 3 copies of GACGTT motif. CpG ODNs with GACCIT motifs might be used to improve the efficacy of vaccines for ducks. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7956 / 7962
页数：7
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