Efficient synthesis of orthogonally protected spermidine and norspermidine derivatives

被引：3
|
作者：
Andruszkiewicz, R [1 ]
Radowski, M [1 ]
Czajgucki, Z [1 ]
机构：
[1] Gdansk Univ Technol, Dept Pharmaceut Technol & Biochem, PL-80952 Gdansk, Poland
来源：
SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 08期
关键词：
Michael addition; polyamines; protecting groups; reduction;
D O I：
10.1081/SCC-200054211
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several orthogonally protected spermidine and norspermidine derivatives have been synthesized via cyanoethylation of monoprotected 1,4-butanediamine (putrescine) or 1,3-propanediamine followed by protection of their secondary amino groups and final reduction of the nitriles; with lithium aluminum hydride in etheral solution at 0 degrees C, thus affording protected norspermidine or spermidine that may be used in the synthesis of polyamine amides or may be further functionalized.
引用
收藏
页码：1085 / 1094
页数：10
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