SYNTHESIS OF SOME ETHYL 2-[3-ARYL-5-METHYL-4-OXO-3,4-DIHYDRO THIENO [2,3-d] PYRIMIDIN-2-YLOXY] ACETATES AND THEIR ANTIMICROBIAL ACTIVITY

被引：0
|
作者：
Ashok, D. [1 ]
Goud, P. Satish [1 ]
Shravani, D. [1 ]
Rajaiah, J. [1 ]
Goud, P. Mallikarjun [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 20卷 / 01期
关键词：
ACIDIC CONDITIONS; NITRILES; FACILE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some new ethyl 2-[3-aryl-5-methyl-4-oxo-3,4-dihydro thieno [2,3-d] pyrimidin-2-yloxy] acetates (3a-e) were synthesized by a convenient method involving reaction of ethyl 2-amino-4-methylthiophene-3 carboxylate with aryl isocyanates followed by insitu cyclization in aq sodium hydroxide. All the compounds synthesized were characterized on the basis of their IR, (1)H NMR and mass spectral data and screened for their antimicrobial activity.
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页码：1 / 4
页数：4
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