Vismodegib in the treatment of basal cell carcinoma: indications for clinical practice

被引:7
|
作者
Pinton, Piergiacomo Calzavara [1 ]
Licitra, Lisa [2 ]
Peris, Katia [3 ]
Santoro, Armando [4 ]
Ascierto, Paolo Antonio [5 ]
机构
[1] Univ & Spedali Civili, Dept Dermatol, Brescia, Italy
[2] Ist Nazl Tumori, Head & Neck Canc Unit, I-20133 Milan, Italy
[3] Univ Cattolica Sacro Cuore, Dept Dermatol, I-00168 Rome, Italy
[4] Ist Clin Humanitas IRCCS, Humanitas Canc Ctr, Rozzano, Italy
[5] Ist Nazl Tumori Fdn G Pascale, Melanoma Canc Immunotherapy & Innovat Therapies, Naples, Italy
关键词
adverse events; basal cell carcinoma; clinical practice; vismodegib; HEDGEHOG PATHWAY INHIBITOR; NEOADJUVANT;
D O I
10.2217/fon.15.20
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Basal cell carcinoma (BCC) is a frequent skin cancer which can cause substantial morbidity due to its location on the face, its frequency of relapse and its capacity to invade local tissues. The primary treatment of BCC usually involves surgery or radiotherapy. In patients who have exhausted surgical and radiotherapy options or with metastatic BCC, guidelines recommend the use of the Hedgehog pathway inhibitor vismodegib. This molecule is indicated for the treatment of adults with metastatic BCC, or with locally advanced BCC which has recurred following surgery or who are not eligible to surgery or radiation. This paper aims to provide suggestions on the optimal management of BCC patients treated with vismodegib in clinical practice, according to the large experience gained by a group of Italian dermatologists and oncologists. In particular, the focus of this paper will be on the monitoring of patients and the management of adverse events.
引用
收藏
页码:1429 / 1435
页数:7
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