Photocleavage of DNA by 4′-bromoacetophenone analogs

被引：4
|
作者：
Jeon, R
Wender, PA
机构：
[1] Sookmyung Womens Univ, Coll Pharm, Yongsan Ku, Seoul 140742, South Korea
[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 01期
关键词：
4 '-bromoacetophenone; pyrrolecarboxamide; DNA cleaving agents; phenyl radical;
D O I：
10.1007/BF02976491
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
4'-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducibie DNA cleaving agents. The potential of 4'-bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4'-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.
引用
收藏
页码：39 / 43
页数：5
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