Use of Plasma Metagenomic Next-generation Sequencing for Pathogen Identification in Pediatric Endocarditis

被引：26

作者：

To, Rachel K. ^{[1
]}

Ramchandar, Nanda ^{[2
,3
]}

Gupta, Aamisha ^{[2
,3
]}

Pong, Alice ^{[2
,3
]}

Cannavino, Christopher ^{[2
,3
]}

Foley, Jennifer ^{[3
]}

Farnaes, Lauge ^{[3
,4
]}

Coufal, Nicole G. ^{[2
,4
]}

机构：

[1] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Chicago, IL USA

[2] Univ Calif San Diego, Dept Pediat, San Diego, CA 92093 USA

[3] Rady Childrens Hosp San Diego, San Diego, CA USA

[4] Rady Childrens Inst Genom Med, San Diego, CA USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 05期

关键词：

infectious endocarditis; metagenomics; next-generation sequencing; INFECTIVE ENDOCARDITIS;

D O I：

10.1097/INF.0000000000003038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pediatric infective endocarditis incurs significant morbidity and generally occurs among children with underlying heart disease. Identification of a pathogen is critical in determining appropriate therapy. However, standard diagnostic testing has limited sensitivity. We describe a case series of children with infective endocarditis in whom plasma next-generation sequencing (Karius, Redwood, CA) identified an organism in 8 of 10 cases.

引用

页码：486 / 488

页数：3

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