In vivo neuroimaging through the highly scattering tissue via iterative multi-photon adaptive compensation technique

被引：31
|
作者：
Kong, Lingjie [1 ]
Cui, Meng [1 ]
机构：
[1] Howard Hughes Med Inst, Ashburn, VA 20147 USA
来源：
OPTICS EXPRESS | 2015年 / 23卷 / 05期
关键词：
2-PHOTON MICROSCOPY; TURBID LAYERS; LIGHT; MEDIA; TIME; RESOLUTION; OPTICS; VOLUMES; CORNERS;
D O I：
10.1364/OE.23.006145
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
For in vivo deep tissue imaging, high order wavefront measurement and correction is needed for handling the severe wavefront distortion. Towards such a goal, we have developed the iterative multi-photon adaptive compensation technique (IMPACT). In this work, we explore using IMPACT to perform calcium imaging of neocortex through the intact skull of adult mice, and to image through the highly scattering white matter on the hippocampus surface. (C) 2015 Optical Society of America
引用
收藏
页码：6145 / 6150
页数：6
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