LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma

被引：12
|
作者：
Li, Zhibing [1 ]
Li, Yijian [2 ]
Wang, Qibai [3 ]
机构：
[1] Shanxi Prov Tumor Hosp, Dept Neurol, Taiyuan 030003, Shanxi, Peoples R China
[2] Tradit Chinese Med Hosp Juye Cty, Dept Surg 2, Heze 274900, Shandong, Peoples R China
[3] Jiangbei Dist Peoples Hosp, Hosp Chongqing Red Cross Soc, Dept Neurol, Chongqing 400025, Peoples R China
来源：
BIOSCIENCE REPORTS | 2018年 / 38卷
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED APOPTOSIS; ADAPTER PROTEIN; TRIP6; PROMOTES; CANCER; OVEREXPRESSION; PROGRESSION; P27(KIP1);
D O I：
10.1042/BSR20181039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
LINC00675 has been suggested to be dysregulated in gastric cancer, colorectal cancer and pancreatic cancer. However, the expression status and biological function of LINC00675 in glioma were still unknown. Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Moreover, univariate and multivariate analyses suggested that high-expression of LINC00675 was an independent unfavorable prognostic predictor for glioma. In addition, levels of LINC00675 expression were positively correlated with TRIP6 mRNA and protein expressions. The in vitro experiment showed that silencing of LINC00675 inhibits glioma cell proliferation, migration and invasion through regulating TRIP6. In conclusion, LINC00675 acts as a tumor promoter in glioma progression.
引用
收藏
页码：1 / 10
页数：10
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