Effect of isocordoin in the release of TGF-β1 of mice with L5178Y lymphoma

被引：0
|
作者：
Puebla-Perez, AM. [1 ,2 ]
Herrera-Hernandez, RA. [1 ]
Villasenor-Garcia, MM. [1 ,2 ]
Viveros-Paredes, J. [2 ]
Delgado-Saucedo, J. [1 ]
Gallegos-Arreola, MP. [1 ]
Borges-Argaez, R. [3 ]
机构：
[1] Inst Mexicano Seguro Social, Ctr Invest Biomed Occidente, Sierra Mojada 800, Guadalajara 44340, Jalisco, Mexico
[2] Univ Guadalajara, Dept Farmacobiol, Ctr Univ Ciencias Exactas & Ingn, Guadalajara, Jalisco, Mexico
[3] Ctr Invest Cient Yucatan, Unidad Biotecnol, Merida 97200, Yucatan, Mexico
来源：
13TH INTERNATIONAL CONGRESS OF IMMUNOLOGY | 2007年
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Isocordoin, natural chalcone isolated of the root of Lonchocarpus xuul with antiprotozoal activity and cytotoxic effect in different tumoral lines. In the other hand, mice with L5178Y lymphoma (L51) present an immunosuppressive status and several studies have shown that TGF-beta 1 is a potent immunosuppressive molecule. The aim of this study was to investigate the effect of isocordoin on TGF-beta 1 levels in mice with L51. Three groups of BALB/c mice: healthy (CT), with lymphoma (L51), and with lymphoma and isocordoin treatment (L51+ISO; 50mg/kg/3 sessions). The treatment started 4 days after the inoculation of the tumor. At 17(th) day of tumor evolution TGF-beta 1 was measured in fluids. The L51+ISO ascitis group shows significant decrease (p < 0.05) with respect to L51 group. In plasma TGF-beta 1 was decreased in L51 group and recovered with isocordoin. Conclusion: Isocordoin possesse antitumoral activity and modulate TGF-beta 1 concentration in ascitis and plasma of lymphoma bearing mice. Keywords: Antitumour activity; chalcone; isocordoin; L5178Y lymphoma; TGF-beta 1.
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页码：167 / +
页数：3
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