Synthesis of 2-Aryl-Substituted Chromans by Intramolecular C-O Bond Formation

被引：14
|
作者：
Wang, Yu [1 ]
Franzen, Robert [1 ]
机构：
[1] Tampere Univ Technol, Dept Chem & Bioengn, FIN-33101 Tampere, Finland
来源：
SYNLETT | 2012年 / 06期
关键词：
intramolecular cyclization; chromans; chalcones; palladium; copper; QUINONE METHIDES; INDPHOX-LIGANDS; ARYL BROMIDES; GENERATION; ARYLATION; CATALYST; PART;
D O I：
10.1055/s-0031-1290607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic route for the preparation of 2-aryl-substituted chromans from commercially available starting materials and utilizing either a palladium-or copper-catalyzed intramolecular cyclization of aryl bromides is described. Chromans with stereocontrol at C-2 can thus be obtained via a palladium-catalyzed asymmetric allylic etherification procedure utilizing a chiral indole-phosphine oxazoline (IndPHOX) ligand.
引用
收藏
页码：925 / 929
页数：5
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