Impact of different endometrial preparation protocols before frozen embryo transfer on pregnancy outcomes: a review

The use of frozen embryo transfer cycles has exponentially increased in the last few years. Optimization of endometrial preparation protocols before frozen embryo transfer is mandatory to further improve pregnancy outcomes. This review will focus on the existing literature with regard to the different available endometrial preparation protocols and their impact on pregnancy outcomes. More spe-cifically, we will focus on programmed, natural, and stimulated frozen embryo transfer cycles. The studies performed on this topic are generally of low quality, and only a few well-performed randomized controlled trials have been published. To date, no strong evidence is available to support the use of 1 preparation method over another in terms of pregnancy outcomes. However, robust data have shown a clearly protective effect of natural frozen embryo transfer cycles against long-term obstetric complications, mainly hypertensive dis-orders of pregnancy and large for gestational age infants. The introduction of individualized luteal phase support in different endome-trial preparation protocols is actually gaining a lot of attention and requires further investigation. (Fertil Sterile 2022;118:820-7.(c) 2022 by American Society for Reproductive Medicine.)