Outcome of Different Endometrial Preparation Protocols Prior to Frozen-Thawed Embryo Transfer on Pregnancy Outcomes in Women with Repeated Implantation Failure

被引:0
|
作者
Xiu, Yin-Ling [1 ]
Sun, Kai-Xuan [1 ]
Zhang, Qian [1 ]
Xiao, Yu-Hong [1 ]
Bai, Xue [1 ]
Chen, Yong [1 ]
Zhao, Meng-Si [1 ]
Yu, Yue-Xin [1 ]
机构
[1] Gen Hosp Northern Theater Command, Ctr Reprod Med, 83 Wenhua Rd, Shenyang 110016, Peoples R China
来源
关键词
endometrial scratching; depot GnRH agonist; repeated implantation failure; blastocysts; clinical pregnancy rate; live birth; rate; CONTROLLED OVARIAN STIMULATION; LOCAL INJURY; RECEPTIVITY; FERTILIZATION; INFLAMMATION; DEFINITION; DIAGNOSIS; SCRATCH; CYCLES;
D O I
10.2147/IJWH.S433640
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: To compare the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles among women with repeated implantation failure (RIF) treated with various endometrial preparation protocols. Methods: A total of 605 women with RIF were retrospectively recruited between January 2017 and December 2020 from Northern Theater General Hospital. Patients were divided into natural cycles, hormone replacement therapy (HRT) cycles, depot gonadotropinreleasing hormone (GnRH) agonist-HRT, and endometrial scratching (ES) plus depot GnRH agonist-HRT. The primary endpoint was clinical pregnancy rate, while secondary endpoints included live birth rate and pain assessment. Results: Of the 605 recruited patients, 63 were undergoing natural cycles, 281 were treated with HRT cycles, 141 treated with depot GnRH agonist-HRT, and 120 treated with ES combined with depot GnRH agonist-HRT. There were significant differences among protocols on clinical pregnancy rate (P=0.029), while no significant difference was observed among protocols on live birth rates (P=0.108). Multivariate analyses suggested that HRT (odds ratio [OR]: 0.50; 95% confidence interval [CI]: 0.28-0.89; P=0.019) and depot GnRH agonist-HRT (OR: 0.49; 95% CI: 0.27-0.91; P=0.021) cycles were associated with a lower clinical pregnancy rate as compared with natural cycles, while no significant difference between ES combined with depot GnRH agonist-HRT and natural cycles for clinical pregnancy rates (OR: 0.72; 95% CI: 0.38-1.36; P=0.313). Moreover, the HRT (OR: 0.70; 95% CI: 0.39-1.28; P=0.239), depot GnRH agonist-HRT (OR: 0.67; 95% CI: 0.35-1.29; P=0.229), and ES combined with depot GnRH agonist-HRT (OR: 1.11; 95% CI: 0.58-2.14; P=0.754) cycles had no significant effects on live birth rate as compared with natural cycles. A total of 87.50% patients treated with ES combined with depot GnRH agonist-HRT reported pain during the procedure. Conclusion: ES and depot GnRH agonists could be considered for RIF women with high-quality blastocysts, 14 days after verified transplantation failure.
引用
收藏
页码:1835 / 1844
页数:10
相关论文
共 50 条
  • [1] Evaluation of Embryo Transfer Outcomes with Different Endometrial Preparation Protocols in Frozen-Thawed Embryo Transfer Cycles
    Xia, Yan
    Lian, Bing
    Li, Shi-fen
    Lin, Dan-huan
    Zhang, Meng-li
    Liu, Lu
    Qin, Chun-rong
    [J]. JOURNAL OF REPRODUCTIVE MEDICINE, 2021, 66 (11-12) : 327 - 336
  • [2] Endometrial preparation using gonadotropin-releasing hormone agonist prior to frozen-thawed embryo transfer in women with repeated implantation failure: An RCT
    Davar, Robab
    Dashti, Saeideh
    Omidi, Marjan
    [J]. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE, 2020, 18 (05) : 319 - 326
  • [3] Different endometrial preparation protocols yield similar pregnancy outcomes for frozen-thawed embryo transfer in patients with advanced endometriosis
    Hai-yan GUO
    Yun WANG
    Qiu-ju CHEN
    Wei-ran CHAI
    Li-hua SUN
    Ai AI
    Yong-lun FU
    Qi-feng LYU
    Yan-ping KUANG
    [J]. Journal of Reproduction and Contraception, 2016, (01) : 1 - 11
  • [4] Injury to the endometrium prior to the frozen-thawed embryo transfer cycle improves pregnancy rates in patients with repeated implantation failure
    Kanazawa, Emiko
    Nakashima, Akira
    Yonemoto, Koji
    Otsuka, Misako
    Yoshioka, Naomi
    Kuramoto, Takeshi
    Mitao, Hiroshi
    Imaishi, Hiroto
    Komai, Kan
    Ushijima, Kimio
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2017, 43 (01) : 128 - 134
  • [5] Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis
    Jingdi Yang
    Yangxing Wen
    Danping Li
    Xuerong Hou
    Bo Peng
    Zengyan Wang
    [J]. Reproductive Biology and Endocrinology, 21
  • [6] Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis
    Yang, Jingdi
    Wen, Yangxing
    Li, Danping
    Hou, Xuerong
    Peng, Bo
    Wang, Zengyan
    [J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2023, 21 (01)
  • [7] The effect of endometrial injury on reproductive outcomes of frozen-thawed embryo transfer cycles in women with one implantation failure
    Chen, Ting
    Shi, Hao
    Fang, Lan Lan
    Su, Ying Chun
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2020, 48 (03)
  • [8] Clinical outcomes and placental pathological characteristics after fresh embryo transfer and frozen-thawed embryo transfer with different endometrial preparation protocols
    Liu, Yuanying
    Li, Rong
    Wang, Yongqing
    [J]. PLACENTA, 2023, 131 : 65 - 70
  • [9] Effects of different endometrial preparation on birthweight of frozen-thawed embryo transfer
    Ding, Jinli
    Zhang, Yi
    Yin, Tailang
    Yang, Jing
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (07): : 14922 - 14928
  • [10] EFFECT OF ENDOMETRIAL INJURY ON REPRODUCTIVE OUTCOMES OF FROZEN-THAWED EMBRYO TRANSFER CYCLES IN WOMEN WITH ONE IMPLANTATION FAILURE.
    Chen, T.
    Su, Y.
    [J]. FERTILITY AND STERILITY, 2018, 110 (04) : E368 - E368