A straightforward metal-free synthesis of 2-substituted thiazolines in air

被引：19
|
作者：
Trose, Michael [1 ]
Lazreg, Faima [1 ]
Lesieur, Mathieu [1 ]
Cazin, Catherine S. J. [1 ]
机构：
[1] Univ St Andrews, EaStCHEM, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
来源：
GREEN CHEMISTRY | 2015年 / 17卷 / 05期
关键词：
SOLVENT-FREE CONDITIONS; N-HETEROCYCLIC CARBENE; CHIRAL LIGANDS; 2-THIAZOLINES; COMPLEXES; OXAZOLINES; CYCLODEHYDRATION; IMIDAZOLINES; CATALYSTS; ACID;
D O I：
10.1039/c5gc00286a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A base-catalysed procedure for the synthesis of 2-substituted thiazolines from nitriles and cysteamine hydrochloride under solvent-free conditions is presented. This straightforward approach allows high conversion for a broad range of nitriles and an easy isolation of the desired products.
引用
收藏
页码：3090 / 3092
页数：3
相关论文
共 50 条
  • [1] Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates
    Liu, Zhen
    Zhang, Yan-Shun
    Wei, Yin
    Shi, Min
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 2020 (09) : 1093 - 1099
  • [2] SINGLE-STEP SYNTHESIS OF 2-SUBSTITUTED 2-THIAZOLINES
    SUZUKI, N
    IZAWA, Y
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1976, 49 (11) : 3155 - 3158
  • [3] A Base- and Metal-free Protocol for the Synthesis of 2-Aryl/heteroaryl Thiazolines
    Chaudhary, Shweta
    Milton, Marilyn D.
    Garg, Parul
    CHEMISTRYSELECT, 2017, 2 (02): : 650 - 654
  • [4] HYDROLYSIS OF 2-SUBSTITUTED DELTA-THIAZOLINES
    MARTIN, RB
    PARCELL, A
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (23) : 4830 - &
  • [5] Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
    Sun, Hongnan
    Huang, Binbin
    Lin, Run
    Yang, Chao
    Xia, Wujiong
    BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2015, 11 : 524 - 529
  • [6] A simple metal-free synthesis of 2-substituted pyridine-4,5-dicarboxylates and their N-oxides
    Bezensek, Jure
    Prek, Benjamin
    Groselj, Uros
    Kasunic, Marta
    Svete, Jurij
    Stanovnik, Branko
    TETRAHEDRON, 2012, 68 (24) : 4719 - 4731
  • [7] Mild, metal-free synthesis of 2-substituted quinazolinones from imidates and methyl 2-aminobenzoates or 2-aminobenzamides
    Zhao, Hongyi
    Wu, Yanan
    Zhang, Dongfeng
    Huang, Haihong
    TETRAHEDRON, 2022, 115
  • [8] Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
    Zhang, Changjun
    Wei, Tingting
    Yu, Zhichen
    Ding, Yuxin
    Su, Weike
    Xie, Yuanyuan
    RSC ADVANCES, 2023, 13 (08) : 4958 - 4962
  • [9] One pot synthesis of 2-substituted thiobenzoazoles containing α-sulfenylated aromatic ketones under transition metal-free conditions
    Cheng, Xi
    Xu, Xiao-Hu
    Dong, Zhi-Bing
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023, 60 (10) : 1793 - 1798
  • [10] STUDIES ON 2-SUBSTITUTED THIAZOLINES .2. REACTIONS WITH RHODANINES
    KURUMI, M
    OKUTOME, T
    SAKURAI, Y
    SATO, S
    YAMAGUCH.K
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1973, 21 (07) : 1431 - 1435
12345