Stimulating and inhibitory effects of the dopamine "stabilizer" (-)-OSU6162 on dopamine D2 receptor function in vitro

被引：18

作者：

Lahti, R. A.

Tamminga, C. A.

Carlsson, A.

机构：

[1] Univ Gothenburg, Dept Pharmacol, Sahlgrenska Acad, S-41319 Gothenburg, Sweden

[2] Univ Maryland, Maryland Psychiat Res Ctr, Baltimore, MD USA

[3] UT SW Med Sch, Dept Psychiat, Dallas, TX USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 09期

关键词：

partial dopamine agonist; dopamine; GTPgammaS(35); psychosis;

D O I：

10.1007/s00702-007-0784-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of (-)-OSU6162 on the incorporation of GTPgammaS(35) in the membranes of hD(2l)-transfected CHO cells was investigated. In the absence of dopamine the compound exerted a slight but significant stimulating action, suggesting a weak partial agonism. In the presence of dopamine, low concentrations (10 to 100 nM) enhanced the stimulating action of dopamine. This enhancing effect was reversed by higher concentrations of (-)-OSU6162 in a complex biphasic manner. The dopamine-enhancing action is proposed to be mediated by binding to an allosteric site with high affinity and the inhibitory component by a low-affinity binding to the orthosteric site of the dopamine receptor.

引用

页码：1143 / 1146

页数：4

共 50 条

[21] Effects of a dopamine stabilizer, OSU-6162, on electrical brain stimulation reward
Benaliouad, F.
Rompre, P. P.
Kapur, S.
Natesan, S.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 : S272 - S272
[22] The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor
K Sahlholm
P Århem
K Fuxe
D Marcellino
Molecular Psychiatry, 2013, 18 : 12 - 14
[23] The dopamine stabilizer (-)-OSU6162 reduces aggressive behaviour in mice at a dose affecting neither social interaction nor locomotion
Studer, E.
Naeslund, J.
Carlsson, A.
Eriksson, E.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2014, 17 : 166 - 166
[24] The Dopamine Stabilizer OSU6162 Alleviates Long-Term Mental Fatigue After Traumatic Brain Injury or Stroke
Johansson, Birgitta
Carlsson, Arvid
Carlsson, Maria L.
Nilsson, Marie K. L.
Nordquist-Brandt, Elisabeth
Ronnback, Lars
BRAIN INJURY, 2012, 26 (4-5) : 622 - 622
[25] THE MONOAMINE STABILIZER (-)-OSU6162 ATTENUATES VOLUNTARY ETHANOL INTAKE AND ETHANOL-INDUCED DOPAMINE OUTPUT IN THE NUCLEUS ACCUMBENS
Steensland, P.
Fredriksson, I.
Holst, S.
Feltmann, K.
Franck, J.
Schilstrom, B.
Carlsson, A.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 37 : 306A - 306A
[26] The Monoamine Stabilizer (-)-OSU6162 Attenuates Voluntary Ethanol Intake and Ethanol-Induced Dopamine Output in Nucleus Accumbens
Steensland, Pia
Fredriksson, Ida
Holst, Sarah
Feltmann, Kristin
Franck, Johan
Schilstrom, Bjorn
Carlsson, Arvid
BIOLOGICAL PSYCHIATRY, 2012, 72 (10) : 823 - 831
[27] Preclinical Evaluation of the Monoamine Stabilizer (-)-OSU6162's Abuse Liability, Effect on Impulsivity and Dopamine Output in the N.Accumbens
Steensland, Pia
Feltmann, Kristin
Fredriksson, Ida
Wirf, Malin
Schilstrom, Bjorn
Carlsson, Arvid
BIOLOGICAL PSYCHIATRY, 2014, 75 (09) : 393S - 394S
[28] Effect of the dopamine stabilizer (-)-OSU6162 on potentiated incubation of opioid craving after electric barrier-induced voluntary abstinence
Ida Fredriksson
Sarah V. Applebey
Angelica Minier-Toribio
Aniruddha Shekara
Jennifer M. Bossert
Yavin Shaham
Neuropsychopharmacology, 2020, 45 : 770 - 779
[29] The monoamine stabilizer (-)-OSU6162 counteracts downregulated dopamine output in the nucleus accumbens of long-term drinking Wistar rats
Feltmann, Kristin
Fredriksson, Ida
Wirf, Malin
Schilstrom, Bjorn
Steensland, Pia
ADDICTION BIOLOGY, 2016, 21 (02) : 438 - 449
[30] Effect of the dopamine stabilizer (-)-OSU6162 on potentiated incubation of opioid craving after electric barrier-induced voluntary abstinence
Fredriksson, Ida
Applebey, Sarah, V
Minier-Toribio, Angelica
Shekara, Aniruddha
Bossert, Jennifer M.
Shaham, Yavin
NEUROPSYCHOPHARMACOLOGY, 2020, 45 (05) : 770 - 779

← 1 2 3 4 5 →