6-amino-9-(carboxymethyl)-2-methoxypurine methyl ester

被引：3
|
作者：
Sood, G [1 ]
Schwalbe, CH [1 ]
Fraser, W [1 ]
机构：
[1] Aston Univ, Inst Pharmaceut Sci, Birmingham B4 7ET, W Midlands, England
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1998年 / 54卷
关键词：
D O I：
10.1107/S0108270197015795
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The hydrogenolysis of 6-azido-9-(carboxymethyl)-2-methoxypurine methyl ester, (3), formed in a single step from 2,6-dichloro-9-(carboxymethyl)purine ethyl ester, (2), gave the title compound, C9H11N5O3, (1) The side chain attached at N9 avoids steric hindrance with the heterocycle by emerging almost orthogonally [C8-N9-C10-C11 -104.5(2)degrees] and the amino group at N6 donates intermolecular hydrogen bonds to the ring N1 and ester carbonyl O11 atoms.
引用
收藏
页码：659 / 661
页数：3
相关论文
共 50 条
  • [1] 2,6-diazido-9-(carboxymethyl)purine methyl ester
    Sood, G
    Schwalbe, CH
    Fraser, W
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 : 608 - 610
  • [2] ANTICOCCIDIAL AND TOLERANCE STUDIES IN CHICKEN WITH 2 6-AMINO-9-(SUBSTITUTED BENZYL)PURINES
    MILLER, BM
    MCMANUS, EC
    OLSON, G
    SCHLEIM, KD
    VANIDERSTINE, AA
    GRAHAM, DW
    BROWN, JE
    ROGERS, EF
    POULTRY SCIENCE, 1977, 56 (06) : 2039 - 2044
  • [3] IDENTIFICATION OF 6-AMINO-9-(2-CHLORO-6-FLUOROBENZYL)PURINE-1-N-OXIDE, A URINARY METABOLITE OF 6-AMINO-9-(2-CHLORO-6-FLUOROBENZYL)PURINE MK-302, ARPRINOCID
    JACOB, TA
    BUHS, RP
    ROSEGAY, A
    CARLIN, J
    VANDENHEUVEL, WJA
    WOLF, FJ
    FEDERATION PROCEEDINGS, 1978, 37 (03) : 813 - 813
  • [4] EFFECT OF 6-AMINO-9-(SUBSTITUTED BENZYL)PURINES ON OOCYST SPORULATION
    TAMAS, T
    OLSON, G
    SMITH, DA
    MILLER, BM
    POULTRY SCIENCE, 1978, 57 (02) : 381 - 385
  • [5] ALKYLATION OF ADENOSINE DEAMINASE WITH BENZYLBROMOACETATE AND 6-AMINO-9-[PARA(2-BROMOACETAMIDO)BENZYL]PURINE
    LUCACCHI.A
    GALBANI, P
    RONCA, G
    BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE, 1970, 46 (20A): : 174 - &
  • [6] 9-(carboxymethyl)-6-chloropurine ethyl ester
    Sood, G
    Schwalbe, CH
    Fraser, W
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 : 1907 - 1909
  • [7] 2'-ESTER PRODRUGS OF THE VARICELLA-ZOSTER ANTIVIRAL AGENT, 6-METHOXYPURINE ARABINOSIDE
    CHAMBERLAIN, SD
    MOORMAN, AR
    JONES, LA
    DEMIRANDA, P
    REYNOLDS, DJ
    KOSZALKA, GW
    KRENITSKY, TA
    ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1992, 3 (06): : 371 - 378
  • [8] 2-AMINO-6-METHOXYPURINE ARABINOSIDE - AN AGENT FOR T-CELL MALIGNANCIES
    LAMBE, CU
    AVERETT, DR
    PAFF, MT
    REARDON, JE
    WILSON, JG
    KRENITSKY, TA
    CANCER RESEARCH, 1995, 55 (15) : 3352 - 3356
  • [9] MICROSOMAL CONVERSION OF MK-302, ARPRINOCID, [6-AMINO-9-(2-CHLORO-6-FLUOROBENZYL)PURINE] TO 6-AMINO-9-(2-CHLORO-6-FLUOROBENZYL)PURINE-1-N-OXIDE BY LIVER-MICROSOMES FROM CHICKEN AND DOG AND TO 2-CHLORO-6-FLUOROBENZYL ALCOHOL BY LIVER-MICROSOMES FROM RAT AND MOUSE
    WOLF, FJ
    STEFFENS, JJ
    ALVARO, RF
    JACOB, TA
    FEDERATION PROCEEDINGS, 1978, 37 (03) : 814 - 814
  • [10] 2,6-diamino-9-(carboxymethyl)purine ethyl ester
    Sood, G
    Schwalbe, CH
    Fraser, W
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 : 1624 - 1626
12345