Epstein-Barr virus encephalitis in a patient with rheumatoid arthritis

被引：2
|
作者：
Nakamura, Jun [1 ]
Yanagida, Mai [1 ]
Saito, Keisuke [1 ]
Kamata, Yasuyuki [1 ]
Nagashima, Takao [1 ]
Iwamoto, Masahiro [1 ]
Sato, Takeo [1 ]
Sato, Kojiro [1 ]
机构：
[1] Jichi Med Univ, Dept Med, Div Rheumatol & Clin Immunol, Yakushiji 3311-1, Shimotsuke, Tochigi 3290498, Japan
来源：
MODERN RHEUMATOLOGY CASE REPORTS | 2022年 / 6卷 / 02期
关键词：
Disease-modifying anti-rheumatic drugs; encephalitis; Epstein-Barr virus; JAK inhibitors; rheumatoid arthritis; TERM-FOLLOW-UP; INFECTIONS;
D O I：
10.1093/mrcr/rxab045
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 53-year-old woman with a 6-year history of rheumatoid arthritis (RA) presented with pharyngeal pain, fever, and altered mental status. The patient had been treated with methotrexate (MTX) 12 mg/week, baricitinib 4 mg/day, and tacrolimus 2 mg/day. Magnetic resonance imaging of the brain revealed diffuse high-intensity lesions in the cerebral white matter, basal ganglia, brainstem, and right cerebellar hemisphere. She was diagnosed with Epstein-Barr virus (EBV) encephalitis due to elevated levels of EBV-DNA in the cerebrospinal fluid and serum. Although MTX-associated lymphoproliferative disorders are well-known complications in patients with RA, EBV encephalitis requires careful attention for such patients undergoing treatment with multiple potent immunosuppressants.
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页码：160 / 162
页数：3
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