The potential for targeting oncogenic WNT/β-catenin signaling in therapy

被引：22
|
作者：
Ewan, Kenneth B. R. [1 ]
Dale, Trevor C. [1 ]
机构：
[1] Sch Biosci, Carshalton CF10 3US, Surrey, England
来源：
CURRENT DRUG TARGETS | 2008年 / 9卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Wnt; beta-catenin; signaling; dysregulation; cancer; therapy;
D O I：
10.2174/138945008784911787
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
引用
收藏
页码：532 / 547
页数：16
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