The potential for targeting oncogenic WNT/β-catenin signaling in therapy

被引：22
|
作者：
Ewan, Kenneth B. R. [1 ]
Dale, Trevor C. [1 ]
机构：
[1] Sch Biosci, Carshalton CF10 3US, Surrey, England
来源：
CURRENT DRUG TARGETS | 2008年 / 9卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Wnt; beta-catenin; signaling; dysregulation; cancer; therapy;
D O I：
10.2174/138945008784911787
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
引用
收藏
页码：532 / 547
页数：16
相关论文
共 50 条
  • [1] Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
    Grossmann, Tom N.
    Yeh, Johannes T. -H.
    Bowman, Brian R.
    Chu, Qian
    Moellering, Raymond E.
    Verdine, Gregory L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (44) : 17942 - 17947
  • [2] Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
    Hwang, So-Young
    Deng, Xianming
    Byun, Sanguine
    Lee, Chan
    Lee, Seung-Joo
    Suh, Hyunsuk
    Zhang, Jianming
    Kang, Qiaofeng
    Zhang, Ting
    Westover, Kenneth D.
    Mandinova, Anna
    Lee, Sam W.
    [J]. CELL REPORTS, 2016, 16 (01): : 28 - 36
  • [3] Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling
    Koelman, Emma M. R.
    Yeste-Vazquez, Alejandro
    Grossmann, Tom N.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 70
  • [4] PEPTIDE TARGETING OF β-CATENIN INHIBITS ONCOGENIC WNT ACTIVITY
    不详
    [J]. CANCER DISCOVERY, 2012, 2 (10) : 865 - 865
  • [5] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer
    Cheng, Xiaofei
    Xu, Xiangming
    Chen, Dong
    Zhao, Feng
    Wang, Weilin
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2019, 110 : 473 - 481
  • [6] Targeting the Wnt/β-catenin signaling pathway in cancer
    Zhang, Ya
    Wang, Xin
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
  • [7] Targeting the Wnt/β-catenin signaling pathway in cancer
    Ya Zhang
    Xin Wang
    [J]. Journal of Hematology & Oncology, 13
  • [8] Targeting Wnt/β-Catenin Signaling for Cancer Immunotheraoy
    Wang, Bojun
    Tian, Tian
    Kalland, Karl-Henning
    Ke, Xisong
    Qu, Yi
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (07) : 648 - 658
  • [9] MicroRNA Therapy Inhibits Hepatoblastoma Growth In Vivo by Targeting β-Catenin and Wnt Signaling
    Indersie, Emilie
    Lesjean, Sarah
    Hooks, Katarzyna B.
    Sagliocco, Francis
    Ernault, Tony
    Cairo, Stefano
    Merched-Sauvage, Maria
    Rullier, Anne
    Le Bail, Brigitte
    Taque, Sophie
    Grotzer, Michael
    Branchereau, Sophie
    Guettier, Catherine
    Fabre, Monique
    Brugieres, Laurence
    Hagedorn, Martin
    Buendia, Marie-Annick
    Grosset, Christophe F.
    [J]. HEPATOLOGY COMMUNICATIONS, 2017, 1 (02) : 168 - 183
  • [10] Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth
    Penny, Morgan K. K.
    Lerario, Antonio M. M.
    Basham, Kaitlin J. J.
    Chukkapalli, Sahiti
    Mohan, Dipika R. R.
    LaPensee, Chris
    Converso-Baran, Kimber
    Hoenerhoff, Mark J. J.
    Suarez-Fernandez, Laura
    del Rey, Carmen Gonzalez
    Giordano, Thomas J. J.
    Han, Ruolan
    Newman, Erika A. A.
    Hammer, Gary D. D.
    [J]. CANCERS, 2023, 15 (14)
12345