Application of an intramolecular dipolar cycloaddition to an asymmetric synthesis of the fully oxygenated tricyclic core of the stemofoline alkaloids

被引：22

作者：

Carra, Ryan J. ^{[1
]}

Epperson, Matthew T. ^{[2
]}

Gin, David Y. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 17期

关键词：

D O I：

10.1016/j.tet.2008.02.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular non-stabilized azomethine ylide dipolar cycloaddition was applied toward the first non-racemic synthesis of the fully oxygenated bridged pyrrolizidine core (45) of (+)-stemofoline (1) in 11 steps from a commercially available starting material. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3629 / 3641

页数：13

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