terpenes and terpenoids;
Michael reactions;
Heck reactions;
ring transformation;
diazo compounds;
D O I:
10.1016/j.tetlet.2005.07.157
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
The enantioselective synthesis of the ketones 3 which displays the carbon core of NGF-inducing cyathane diterpenes is described. The key tricyclic trienone 22 was assembled in 13 steps from Michael adduct (R)-8a via intramolecular Heck cyclization of the chiral triflate 21. The trienone 22 was further elaborated into ketone 3 through tritnethylaluminum-promoted expansion of the Gring with trimethylsilyldiazomethane. (c) 2005 Elsevier Ltd. All rights reserved.
机构:
Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
Zhang, AM
Lin, GQ
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机构:
Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China