Immunity to seasonal and pandemic influenza A viruses

被引：53

作者：

Valkenburg, Sophie A. ^{[2
]}

Rutigliano, John A. ^{[1
]}

Ellebedy, Ali H. ^{[3
]}

Doherty, Peter C. ^{[1
,2
]}

Thomas, Paul G. ^{[1
]}

Kedzierska, Katherine ^{[2
]}

机构：

[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[3] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

MICROBES AND INFECTION | 2011年 / 13卷 / 05期

基金：

英国医学研究理事会;

关键词：

Influenza virus; Adaptive immunity; Innate immunity; H1N1; 2009; Antigenic variation; T-CELL RESPONSES; ANTIBODY-RESPONSE; DENDRITIC CELLS; STRUCTURAL BASIS; MATRIX PROTEIN; H1N1; VIRUS; PREEXISTING IMMUNITY; TRANSCRIPTION FACTOR; PROTECTIVE IMMUNITY; EARLY ESTABLISHMENT;

D O I：

10.1016/j.micinf.2011.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：489 / 501

页数：13

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