How central is nitric oxide (NO) to the activation of c-fos in spinal neurones following noxious peripheral stimulation in the rat?

被引：13
|
作者：
Nazli, M
Hismiogullari, ES
Thippeswamy, T
Morris, R
机构：
[1] Univ Liverpool, Dept Vet Preclin Sci, Liverpool L69 3BX, Merseyside, England
[2] Ankara Univ, Dept Vet Pharmacol & Toxicol, TR-06100 Ankara, Turkey
[3] Univ Kafkas, Dept Vet Anat, Kars, Turkey
来源：
BRAIN RESEARCH | 2001年 / 888卷 / 01期
基金：
英国惠康基金;
关键词：
nitric oxide; c-fos; spinal cord; pain; nociception;
D O I：
10.1016/S0006-8993(00)03099-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intrathecal application of high doses of NO-donor compounds in the anaesthetised rat was not found to cause any induction of c-fos in spinal neurones. Furthermore, intrathecal injection of a NO-synthase (NOS) blocking drug did not alter the numbers of c-fos positive neurones induced by noxious stimulation. Additionally very little colocalization between NOS and c-fos following noxious stimulation was found. Collectively these data give no support for a role for NO in the noxiously evoked induction of c-fos. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：172 / 175
页数：4
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