Pregnane alkaloids from Pachysandra axillaris

被引：22
|
作者：
Sun, Yun [1 ,2 ,3 ]
Yan, Yu-Xin [1 ,2 ]
Chen, Jian-Chao [1 ]
Lu, Lu [1 ,2 ]
Zhang, Xian-Min [1 ]
Li, Yan [1 ]
Qiu, Ming-Hua [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[3] Yunnan Univ Tradit Chinese Med, Kunming 650000, Yunnan, Peoples R China
来源：
STEROIDS | 2010年 / 75卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Pregnane alkaloids; Pachysandra axillaris; Cytotoxic activity;
D O I：
10.1016/j.steroids.2010.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 mu M. (C) 2010 Published by Elsevier Inc.
引用
收藏
页码：818 / 824
页数：7
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