Ultrastructural diversity of inclusions and aggregations in the lumbar spinal cord of SOD1-G93A transgenic mice

被引：17
|
作者：
Guo, Yansu
Li, Chunyan [1 ]
Wu, Dongxia
Wu, Shuyu
Yang, Cheng
Liu, Yang
Wu, Hongran
Li, Zhongyao
机构：
[1] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China
来源：
BRAIN RESEARCH | 2010年 / 1353卷
基金：
中国国家自然科学基金;
关键词：
Amyotrophic lateral sclerosis; Transgenic mouse; Spinal cord; Ultrastructure; Inclusion; AMYOTROPHIC-LATERAL-SCLEROSIS; CU; ZN SUPEROXIDE-DISMUTASE; ALS-LINKED SOD1; ASTROCYTIC HYALINE INCLUSIONS; MOTOR-NEURON DEATH; SUPEROXIDE-DISMUTASE-1; SOD1; GOLGI-APPARATUS; GENE MUTATION; MOUSE MODEL; NEUROPATHOLOGY;
D O I：
10.1016/j.brainres.2010.07.025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of lumbar spinal cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently according to the specified locations. This study provided further information to the previous reports about pathological changes of ALS. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：234 / 244
页数：11
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