The role of neurogenesis in neurorepair after ischemic stroke

被引：71
|
作者：
Marques, Bruno L. [1 ]
Carvalho, Gustavo A. [1 ]
Freitas, Elis M. M. [1 ]
Chiareli, Raphaela A. [1 ]
Barbosa, Thiago G. [1 ]
Di Araujo, Armani G. P. [1 ]
Nogueira, Yanley L. [1 ]
Ribeiro, Raul I. [1 ]
Parreira, Ricardo C. [1 ]
Vieira, Mariana S. [2 ]
Resende, Rodrigo R. [2 ]
Gomez, Renato S. [3 ]
Oliveira-Lima, Onesia C. [1 ]
Pinto, Mauro C. X. [1 ]
机构：
[1] Univ Fed Goias, Inst Ciencias Biol, Dept Farmacol, Goiania, Go, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, Belo Horizonte, MG, Brazil
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 95卷
关键词：
Stroke; Brain ischemia; Neurogenesis; Brain repair; ENDOTHELIAL GROWTH-FACTOR; NEURAL STEM-CELLS; ADULT HIPPOCAMPAL NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; SUBVENTRICULAR ZONE; PROGENITOR CELLS; FUNCTIONAL RECOVERY; TRANSCRIPTION FACTORS; DENTATE GYRUS; COGNITIVE FUNCTION;
D O I：
10.1016/j.semcdb.2018.12.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. However, this endogenous neurogenesis occurs slowly and does not allow a complete restoration of brain function. Despite that, understanding the mechanisms of neurogenesis could improve the therapeutic strategies for brain repair. This review presents the current knowledge about brain repair process after stroke and the perspectives regarding the development of promising therapies that aim to improve neurogenesis and its potential to form new neural networks.
引用
收藏
页码：98 / 110
页数：13
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