A focus on the association of Apol1 with kidney disease in children

被引：12

作者：

Ekulu, Pepe M. ^{[1
,2
]}

Nkoy, Agathe B. ^{[2
]}

Adebayo, Oyindamola C. ^{[1
]}

Kazadi, Orly K. ^{[2
]}

Aloni, Michel N. ^{[2
]}

Arcolino, Fanny O. ^{[1
]}

Ngiyulu, Rene M. ^{[2
]}

Gini, Jean-Lambert E. ^{[2
]}

Lepira, Francois B. ^{[3
]}

van den Heuvel, Lamberthus P. ^{[1
,4
]}

Levtchenko, Elena N. ^{[5
,6
]}

机构：

[1] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[2] Univ Kinshasa, Div Nephrol, Dept Pediat, Fac Med,Univ Hosp Kinshasa, Kinshasa, DEM REP CONGO

[3] Univ Kinshasa, Div Nephrol, Dept Internal Med, Fac Med,Univ Hosp Kinshasa, Kinshasa, DEM REP CONGO

[4] Radboud Univ Nijmegen, Dept Pediat Nephrol, Med Ctr, Nijmegen, Netherlands

[5] Katholieke Univ Leuven, Dept Pediat Nephrol, Univ Hosp Leuven, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Dev & Regenerat, Univ Hosp Leuven, Leuven, Belgium

来源：

PEDIATRIC NEPHROLOGY | 2021年 / 36卷 / 04期

关键词：

APOL1; Chronic kidney disease; Children; Genetics; Sickle cell disease; HIV-associated nephropathy; STAGE RENAL-DISEASE; AFRICAN-AMERICAN CHILDREN; RISK VARIANTS; APOLIPOPROTEIN L1; NEPHROPATHY; GENE; GENOTYPE; OUTCOMES; ALLELES; ADULTS;

D O I：

10.1007/s00467-020-04553-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been associated with the development of hypertension, albuminuria, and more rapid decline of kidney function. The present review focuses on existing APOL1-related epidemiological data in children with CKD. It also includes data from studies addressing racial disparities in CKD, the APOL1-related innate immunity, and the relationship between APOL1 and CKD and pathogenic pathways mediating APOL1-related kidney injury.

引用

页码：777 / 788

页数：12

共 50 条

[21] Association of Recipient APOL1 Kidney Risk Alleles With Kidney Transplant Outcomes
Roy, Neil
Morales-Alvarez, M. Catalina
Anis, Karim H.
Goral, Simin
Doria, Cataldo
Kopp, Jeffrey B.
Winkler, Cheryl A.
Feng, Rui
Rosas, Sylvia E.
TRANSPLANTATION, 2023, 107 (12) : 2575 - 2580
[22] APOL1 Kidney Disease Risk Variants Are Causal in Obesity
Kearney, Andrew
Yang, Johnson
Liu, Esther
Kong, Jiayi
Wright, Matthew
Lin, Jennie
CIRCULATION, 2024, 150
[23] APOL1 Kidney Disease Risk Variants: An Evolving Landscape
Dummer, Patrick D.
Limou, Sophie
Rosenberg, Avi Z.
Heymann, Jurgen
Nelson, George
Winkler, Cheryl A.
Kopp, Jeffrey B.
SEMINARS IN NEPHROLOGY, 2015, 35 (03) : 222 - 236
[24] APOL1 risk variants drive kidney disease in mice
Allison, Susan J.
NATURE REVIEWS NEPHROLOGY, 2017, 13 (05) : 259 - 259
[25] Hypoxia hits APOL1 in the kidney
Grampp, Steffen
Krueger, Rene
Lauer, Victoria
Uebel, Sebastian
Knaup, Karl X.
Naas, Julia
Hoeffken, Verena
Weide, Thomas
Schiffer, Mario
Naas, Stephanie
Schoedel, Johannes
KIDNEY INTERNATIONAL, 2023, 104 (01) : 53 - 60
[26] APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease
Beckerman, Pazit
Susztak, Katalin
TRENDS IN MOLECULAR MEDICINE, 2018, 24 (08) : 682 - 695
[27] Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry
Reidy, Kimberly J.
Hjorten, Rebecca
Parekh, Rulan S.
CURRENT OPINION IN PEDIATRICS, 2018, 30 (02) : 252 - 259
[28] APOL1 Nephropathy Risk Variant Associations with Diseases beyond the Kidney: APOL1 and Sepsis
Ma, Lijun
Freedman, Barry I.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2019, 14 (12): : 1684 - 1686
[29] Balancing the genetic risk of APOL1 kidney disease variants
Kabore, Nongodo Firmin
Limou, Sophie
NEPHROLOGIE & THERAPEUTIQUE, 2019, 15 : S79 - S84
[30] The Mechanism of Kidney Disease due to APOL1 Risk Variants
Pays, Etienne
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (06): : 818 - 821

← 1 2 3 4 5 →