Combined neutron and X-ray diffraction studies of DNA in crystals and solutions

被引：6

作者：

Leal, Ricardo M. F. ^{[1
,2
,3
]}

Callow, Shirley ^{[1
,2
,3
]}

Callow, Phil ^{[1
,3
]}

Blakeley, Matthew P. ^{[1
]}

Cardin, Christine J. ^{[4
]}

Denny, William A. ^{[5
]}

Teixeira, Susana C. M. ^{[1
,3
]}

Mitchell, Edward P. ^{[2
,3
]}

Forsyth, V. Trevor ^{[1
,3
]}

机构：

[1] Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France

[2] European Synchrotron Radiat Facil, F-38043 Grenoble, France

[3] Univ Keele, EPSAM ISTM, Keele ST5 5BG, Staffs, England

[4] Univ Reading, Dept Chem, Reading RG6 2AH, Berks, England

[5] Univ Auckland, Auckland Canc Soc Res Ctr, Sch Med Sci, Auckland 1, New Zealand

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2010年 / 66卷

基金：

英国工程与自然科学研究理事会;

关键词：

neutron diffraction; X-ray diffraction; nucleic acids; DNA; acridine derivatives; deuteration; SAXS; SANS; FIBER DIFFRACTION; CRYSTALLOGRAPHIC ANALYSIS; PROGRAM; CRYSTALLIZATION; HYDRATION;

D O I：

10.1107/S0907444910017713

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in instrumentation and facilities for sample preparation have resulted in sharply increased interest in the application of neutron diffraction. Of particular interest are combined approaches in which neutron methods are used in parallel with X-ray techniques. Two distinct examples are given. The first is a single-crystal study of an A-DNA structure formed by the oligonucleotide d(AGGGGCCCCT)(2), showing evidence of unusual base protonation that is not visible by X-ray crystallography. The second is a solution scattering study of the interaction of a bisacridine derivative with the human telomeric sequence d(AGGGTTAGGGTTAGGGTTAGGG) and illustrates the differing effects of NaCl and KCl on this interaction.

引用

页码：1244 / 1248

页数：5

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