Copper-Catalyzed N-Formylation of Amines through Tandem Amination/Hydrolysis/Decarboxylation Reaction of Ethyl Bromodifluoroacetate

被引：27
|
作者：
Li, Xiao-Fang [1 ]
Zhang, Xing-Guo [1 ]
Chen, Fan [1 ]
Zhang, Xiao-Hong [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 20期
基金：
中国国家自然科学基金;
关键词：
SOLVENT-FREE CONDITIONS; CARBON-DIOXIDE; ROOM-TEMPERATURE; SODIUM BROMODIFLUOROACETATE; OXIDATIVE FORMYLATION; REFORMATSKY REACTION; MOLECULAR-OXYGEN; SECONDARY-AMINES; MILD CONDITIONS; ARYL BROMIDES;
D O I：
10.1021/acs.joc.8b01555
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ethyl bromodifluoroacetate (BrCF2COOEt) was first used as the N-formylating reagent in the copper-catalyzed N-formylation of amines. A range of primary, secondary, cyclic arylamines, and aliphatic amines underwent the N-formylation smoothly to furnish the N-formamides in moderate-to-excellent yields.
引用
收藏
页码：12815 / 12821
页数：7
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