The Unusual Fold of Herpes Simplex Virus 1 UL21, a Multifunctional Tegument Protein

被引：17
|
作者：
Metrick, Claire M. [1 ,2 ]
Chadha, Pooja [3 ]
Heldwein, Ekaterina E. [1 ,2 ]
机构：
[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
[2] Tufts Univ, Sch Med, Sackler Sch Grad Biomed Sci, Grad Program Biochem, Boston, MA 02111 USA
[3] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA USA
来源：
JOURNAL OF VIROLOGY | 2015年 / 89卷 / 05期
关键词：
PSEUDORABIES VIRUS; BINDING; STRAIN; NEUROINVASION; PREDICTION; EFFECTOR; BARTHA; SPREAD; SERVER; CELLS;
D O I：
10.1128/JVI.03516-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
UL21 is a conserved protein in the tegument of alphaherpesviruses and has multiple important albeit poorly understood functions in viral replication and pathogenesis. To provide a roadmap for exploration of the multiple roles of UL21, we determined the crystal structure of its conserved N-terminal domain from herpes simplex virus 1 to 2.0-angstrom resolution, which revealed a novel sail-like protein fold. Evolutionarily conserved surface patches highlight residues of potential importance for future targeting by mutagenesis.
引用
收藏
页码：2979 / 2984
页数：6
相关论文
共 50 条
  • [41] Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E
    Yeh, Pei-Chun
    Han, Jun
    Chadha, Pooja
    Meckes, David G., Jr.
    Ward, Michael D.
    Semmes, O. John
    Wills, John W.
    JOURNAL OF VIROLOGY, 2011, 85 (18) : 9425 - 9436
  • [42] Bioinformatics Analysis and Characteristics of UL21 Protein from Duck Virus Enteritis
    Shi, Yong
    Cheng, Anchun
    Wang, Mingshu
    AASRI CONFERENCE ON COMPUTATIONAL INTELLIGENCE AND BIOINFORMATICS, 2012, 1 : 124 - 135
  • [43] Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein
    Metrick, Claire M.
    Koenigsberg, Andrea L.
    Heldwein, Ekaterina E.
    MBIO, 2020, 11 (03):
  • [44] The Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis
    Oda, Shinya
    Arii, Jun
    Koyanagi, Naoto
    Kato, Akihisa
    Kawaguchi, Yasushi
    JOURNAL OF VIROLOGY, 2016, 90 (19) : 8754 - 8767
  • [45] CRISPR/Cas9 Mutagenesis of UL21 in Multiple Strains of Herpes Simplex Virus Reveals Differential Requirements for pUL21 in Viral Replication
    Finnen, Renee L.
    Banfield, Bruce W.
    VIRUSES-BASEL, 2018, 10 (05):
  • [46] A Multiple Functional Protein:the Herpes Simplex Virus Type 1 Tegument Protein VP22
    Mei-li LI
    Virologica Sinica, 2009, 24 (03) : 153 - 161
  • [47] Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling (vol 21, e00919, 2019)
    You, Hongjuan
    Zheng, Sisilia
    Huang, Zhiming
    Lin, Yingying
    Shen, Qingtang
    Zheng, Chunfu
    MBIO, 2023, 14 (06):
  • [48] Bovine herpesvirus 1 tegument protein UL21 plays critical roles in viral secondary envelopment and cell-to-cell spreading
    Shahin, Farzana
    Raza, Sohail
    Yang, Kui
    Hu, Changmin
    Chen, Yingyu
    Chen, Huanchun
    Guo, Aizhen
    ONCOTARGET, 2017, 8 (55) : 94462 - 94480
  • [49] Identification of proteins that interact with the UL24 protein of herpes simplex virus 1
    L Bertrand
    A Pearson
    BMC Proceedings, 5 (Suppl 1)
  • [50] The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation
    Fujii, Hikaru
    Kato, Akihisa
    Mugitani, Michio
    Kashima, Yukie
    Oyama, Masaaki
    Kozuka-Hata, Hiroko
    Arii, Jun
    Kawaguchi, Yasushi
    JOURNAL OF VIROLOGY, 2014, 88 (18) : 10624 - 10634
12345