Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins

被引：81
|
作者：
Ketelslegers, JM [1 ]
Maiter, D [1 ]
Maes, M [1 ]
Underwood, LE [1 ]
Thissen, JP [1 ]
机构：
[1] UNIV N CAROLINA, SCH MED, DEPT PEDIAT, CHAPEL HILL, NC 27515 USA
来源：
HORMONE RESEARCH | 1996年 / 45卷 / 3-5期
关键词：
nutrition; growth hormone; insulin-like growth factor; IGF-binding protein;
D O I：
10.1159/000184797
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Both growth hormone (GH) and insulin-like growth factors (IGFs) associate with specific binding proteins. Besides control by hormones, these binding proteins are nutritionally regulated. The GH-binding protein (GHBP) is the extracellular portion of the GH receptor. Its concentrations in circulation are decreased in severe malnutrition, reflecting a decrease in tissue GH receptor abundance. IGFs are bound to 6 different binding proteins (IGFBPs). IGFBP-3 is relatively stable and is only depressed after prolonged periods of severe malnutrition. In contrast, IGFBP-1 is regulated acutely by nutrient intake, showing major elevations after overnight fasting and rapid postprandial decreases. IGFBP-2 is highly dependent on dietary protein intake. Nutritional factors may regulate the tissue availability and the biological actions of IGFs by their actions on IGFBPs.
引用
收藏
页码：252 / 257
页数：6
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