Insulin-like growth factor-binding proteins and bone metabolism

被引：53
|
作者：
Conover, Cheryl A. [1 ]
机构：
[1] Mayo Clin, Div Endocrinol & Metab, Endocrine Res Unit, Dept Med, Rochester, MN 55905 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2008年 / 294卷 / 01期
关键词：
insulin-like growth factors;
D O I：
10.1152/ajpendo.00648.2007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.
引用
收藏
页码：E10 / E14
页数：5
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