Stereoselective synthesis of (-)-microcarpalide

被引：27
|
作者：
Chavan, SP [1 ]
Praveen, C [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期
关键词：
microcarpalide; ring-closing metathesis; sharpless asymmetric dihydroxylation; Claisen ortho ester rearrangement; cis-2-butene-1,4-diol;
D O I：
10.1016/j.tetlet.2005.01.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly convergent and efficient synthesis of (-)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strategy highlights the application of novel hydroxy lactone precursors for the stereoselective synthesis of (-)-microcarpalide. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1939 / 1941
页数：3
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