Alkynylation of heterocyclic compounds using hypervalent iodine reagent

被引：30
|
作者：
Kamlar, M. [1 ]
Cisarova, I. [2 ]
Vesely, J. [1 ]
机构：
[1] Charles Univ Prague, Fac Sci, Dept Organ Chem, Prague 12843 2, Czech Republic
[2] Charles Univ Prague, Dept Inorgan Chem, Fac Sci, Prague 12843 2, Czech Republic
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 10期
关键词：
STRUCTURE-BASED DESIGN; ELECTROPHILIC ALKYNYLATION; RHODANINE DERIVATIVES; CONJUGATE ADDITION; ENDOGENOUS OPIOIDS; INHIBITORS; POTENT; INDOLE; DIPYRONE; ACID;
D O I：
10.1039/c4ob02625j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.
引用
收藏
页码：2884 / 2889
页数：6
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