Molecular pathology and biomarkers of bladder cancer

被引：10
|
作者：
Czerniak, Bogdan [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Div Pathol & Lab Med, Houston, TX 77030 USA
来源：
CANCER BIOMARKERS | 2011年 / 9卷 / 1-6期
关键词：
Bladder cancer; dual-track pathway; genomic map; biomarkers; risk factors; forerunner genes; precursor lesions; field effect; molecular profiling; diagnosis and treatment of bladder cancer; GROWTH-FACTOR RECEPTOR; GENOME-WIDE ASSOCIATION; ABERRANT PROMOTER METHYLATION; TRANSITIONAL-CELL CARCINOMA; IN-SITU HYBRIDIZATION; DNA IMAGE-ANALYSIS; HA-RAS GENE; URINARY-BLADDER; P53; GENE; PROGNOSTIC VALUE;
D O I：
10.3233/CBM-2011-0175
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bladder cancer originates in the epithelial lining of the bladder's mucosa and develops in association with several habitual, industrial, and environmental risk factors via papillary and non-papillary pathways. In this chapter we review novel concepts concerning the molecular mechanisms of early field change in bladder neoplasia stemming from whole-organ genomic mapping studies. These mechanisms are discussed in the context of molecular pathogenesis of bladder cancer and in relation to treatment and biomarker-based detection strategies.
引用
收藏
页码：159 / 176
页数：18
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