In vitro Antigonorrhea Activity of the Aerial Part of Asparagus suaveolens n-Hexane Fraction and Palmitone as a Bioactive Compound

被引：0
|
作者：
Olivier, Mutendela Tabize [1 ]
Muganza, Freddy Munyololo [1 ]
Shai, Leshweni Jeremia [2 ]
Gololo, Stanley Sechene [3 ]
机构：
[1] Sefako Makgatho Hlth Sci Univ, Dept Chem, Molotlegi St, ZA-0204 Pretoria, South Africa
[2] Tshwane Univ Technol, Dept Biomed Sci, P Bag X680, ZA-0001 Pretoria, South Africa
[3] Sefako Makgatho Hlth Sci Univ, Dept Biochem, Molotlegi St, ZA-0204 Pretoria, South Africa
来源：
NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 09期
关键词：
Asparagus suaveolens; Antigonorrhea; Palmitone; Minimum inhibitory concentration; NEISSERIA-GONORRHOEAE; ANTIMICROBIAL RESISTANCE; SURVEILLANCE; INFECTIONS; PREVALENCE; CEFIXIME; PROVINCE; PLANTS; MEN;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Asparagus suaveolens is a medicinal plant used in Lesotho and South Africa to treat epilepsy and gonorrhea. The current investigation identifies the compound responsible for the antiepileptic and antimicrobial properties as palmitone which showed antigonorrhea activities against WHO 2008 Neisseria gonorrhea F and 0 strains more than the standard used, gentamicin. These results support the traditional use of A. suaveolens for treatment of gonorrhea and epilepsy since palmitone is known as an anticonvulsant agent. This is the first study indicating the presence of palmitone in the Asparagus genus and demonstrates the in vitro antigonorrhea activity of palmitone.
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收藏
页码：1319 / 1321
页数：3
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