Impairments of Conditioned Behavior in Adult Rats Induced by Interleukine-1β Treatment in Early Postnatal Ontogenesis

被引:0
|
作者
Zubareva, O. E. [1 ]
Shcherbakova, K. P.
Kalemenev, S. V.
Simbirtsev, A. S.
Klimenko, V. M.
机构
[1] Russian Acad Med Sci, Inst Expt Med, Nord W Div, Moscow 109801, Russia
关键词
interleukin-1; beta; early postnatal ontogenesis; conditioned reaction of active avoidance; conditioned reaction of passive avoidance; LONG-TERM POTENTIATION; BRAIN; EXPRESSION; PERIODS;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Impairments of cognitive functions in children and adolescents are often consequences of perinatal pathology (natal injuries, ischemia, hypoxia, infection and allergic diseases), which are accompanied by enhanced production of proinflammatory cytokine interleukine-1 beta. In this work it was shown that treatment with interleukine-1 beta during the third week of life impaired active and passive avoidance conditioning in adult rats at the age of 60-70 days.
引用
收藏
页码:736 / 741
页数:6
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