Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

被引：84

作者：

Gracia-Lor, Emma ^{[1
,2
]}

Rousis, Nikolaos I. ^{[1
]}

Zuccato, Ettore ^{[1
]}

Bade, Richard ^{[2
,3
]}

Baz-Lomba, Jose Antonio ^{[4
,5
]}

Castrignano, Erika ^{[6
]}

Causanilles, Ana ^{[7
]}

Hernandez, Felix ^{[2
]}

Kasprzyk-Hordern, Barbara ^{[6
]}

Kinyua, Juliet h ^{[8
]}

McCall, Ann-Kathrin ^{[9
]}

van Nuijs, Alexander L. N. ^{[8
]}

Plosz, Benedek G. jk ^{[10
,11
]}

Ramin, Pedram ^{[10
,12
]}

Ryu, Yeonsuk ^{[4
,5
]}

Santos, Miguel M. ^{[13
,14
]}

Thomas, Kevin ^{[4
,15
]}

de Voogt, Pim ^{[7
,16
]}

Yang, Zhugen ^{[6
,17
]}

Castiglioni, Sara ^{[1
]}

机构：

[1] IRCCS Ist Ric Farmacol Mario Negri, Dept Environm Hlth Sci, Via La Masa 19, I-20156 Milan, Italy

[2] Univ Jaume 1, Res Inst Pesticides & Water, Avda Sos Baynat S-N, E-12071 Castellon de La Plana, Spain

[3] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5000, Australia

[4] Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway

[5] Univ Oslo, Fac Med, POB 1078, N-0316 Oslo, Norway

[6] Univ Bath, Dept Chem, Fac Sci, Bath BA2 7AY, Avon, England

[7] KWR Watercycle Res Inst, Chem Water Qual & Hlth, POB 1072, NL-3430 BB Nieuwegein, Netherlands

[8] Univ Antwerp, Dept Pharmaceut Sci, Toxicol Ctr, Campus Drie Eiken,Univ Pl 1, B-2610 Antwerp, Belgium

[9] Eawag, Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland

[10] Tech Univ Denmark, Dept Environm Engn, Bldg 115, DK-2800 Lyngby, Denmark

[11] Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England

[12] Tech Univ Denmark, Dept Chem & Biochem Engn, Bldg 229, DK-2800 Lyngby, Denmark

[13] Univ Porto, CIMAR CIIMAR, Interdisciplinary Ctr Marine & Environm Res, Ave Gen Norton Matos S-N, P-4450208 Matosinhos, Portugal

[14] Univ Porto, Fac Sci, Dept Biol, FCUP, Rua Campo Alegre, P-4169007 Oporto, Portugal

[15] Univ Queensland, QAEHS, 39 Kessels Rd, Coopers Plains, Qld 4108, Australia

[16] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, POB 94248, NL-1090 GE Amsterdam, Netherlands

[17] Univ Glasgow, Sch Engn, Div Biomed Engn, Glasgow G12 8LT, Lanark, Scotland

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2017年 / 609卷

关键词：

Caffeine; 1,7-dimethyluric acid; Back-calculation; Correction factor; Wastewater-based epidemiology; Urinary biomarkers; ILLICIT DRUG-USE; EUROPEAN CITIES; CONSUMPTION; BIOMARKERS; COMMUNITY; COCAINE; SEWAGE; EXPOSURE; NICOTINE; SAFETY;

D O I：

10.1016/j.scitotenv.2017.07.258

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1582 / 1588

页数：7

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