Caffeine and caffeine metabolites in relation to hypertension in US adults

被引:23
|
作者
Ngueta, Gerard [1 ,2 ,3 ]
机构
[1] Univ Laval, Fac Pharm, Quebec City, PQ, Canada
[2] Inst Natl Sante Publ Quebec, Bur Informat & Etud Sante Populat, Quebec City, PQ, Canada
[3] Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada
关键词
COFFEE CONSUMPTION; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; SYSTEMATIC ANALYSIS; INSULIN-RESISTANCE; RISK; MEN; METAANALYSIS; LIPIDS; WOMEN;
D O I
10.1038/s41430-019-0430-0
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background/Objectives Most studies assessing the association between coffee consumption and hypertension ascertained caffeine intake in terms of number of cups per days, and yield mixed results. Although the inter-individuals variability in the caffeine metabolism is known, the relation of caffeine metabolites with hypertension remains unsettled. We examined the association of caffeine and 13 direct and indirect caffeine metabolites with hypertension in U.S. adults. Methods Using data from 2009-2010 National Health and Nutrition Examination Survey, we included 2278 individuals aged 18 to 80 years. Urinary methyluric acids (MU) and methylxanthines (MX) products of caffeine metabolism were measured using high performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry. We used multivariate logistic regression to model hypertension (systolic blood pressure >= 130 mmHg or diastolic blood pressure >= 80 mmHg) as functions of urinary coffee metabolites. Results The odds of hypertension decreased across quartiles of 3-MU, 7-MU, 3-MX and 7-MX, with 7-MU being the more powerful metabolite. Compared with adults in the bottom quartile of 7-MU, the odds of hypertension decreased by 81% (95% CI: -90 to -22%) in those in the upper quartile. In contrast, the odds ratio for being hypertensive from the bottom to the upper quartile were 4.47 (95% CI: 1.21-16.50) for 1,3-dimethyluric acid, 4.45 (95% CI: 1.48-13.39) for 1,3-dimethylxanthine, and 5.08 (95% CI: 1.11-23.36) for 1,7-dimethylxanthine. Neither insulin resistance nor abdominal obesity were moderators in these associations. Conclusions Final metabolites of caffeine (namely 3-MU, 7-MU, 3-MX and 7-MX), but not caffeine, significantly reduce the odds for hypertension in this population.
引用
收藏
页码:77 / 86
页数:10
相关论文
共 50 条
  • [1] Caffeine and caffeine metabolites in relation to hypertension in U.S. adults
    Gerard Ngueta
    [J]. European Journal of Clinical Nutrition, 2020, 74 : 77 - 86
  • [2] Caffeine and Caffeine Metabolites in Relation to Insulin Resistance and Beta Cell Function in US Adults
    Lee, Sohyae
    Min, Jin-young
    Min, Kyoung-bok
    [J]. NUTRIENTS, 2020, 12 (06) : 1 - 13
  • [3] Associations of urinary caffeine and caffeine metabolites with metabolic syndrome in US adults
    Zhou, Jianli
    Qin, Linyuan
    [J]. FRONTIERS IN NUTRITION, 2023, 10
  • [4] Urinary caffeine and caffeine metabolites and lung function in a nationwide study of US adults
    Han, Yueh-Ying
    Forno, Erick
    Celedon, Juan
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [5] Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of US adults
    Han, Yueh-Ying
    Forno, Erick
    Celedon, Juan C.
    [J]. JOURNAL OF ASTHMA, 2022, 59 (11) : 2127 - 2134
  • [6] Urine Excretion of Caffeine and Select Caffeine Metabolites Is Common in the US Population and Associated with Caffeine Intake
    Rybak, Michael E.
    Sternberg, Maya R.
    Pao, Ching-I
    Ahluwalia, Namanjeet
    Pfeiffer, Christine M.
    [J]. JOURNAL OF NUTRITION, 2015, 145 (04): : 766 - 774
  • [7] Principal Components Analysis of Urine Caffeine and Caffeine Metabolites in the US Population
    Pao, Ching-I
    Rybak, Michael
    Sternberg, Maya
    Ahluwalia, Namanjeet
    Pfeiffer, Christine
    [J]. FASEB JOURNAL, 2015, 29
  • [8] Association of urinary caffeine and caffeine metabolites with cardiovascular disease risk in adults
    Weng, Zhenkun
    Xu, Cheng
    Xu, Jin
    Jiang, Zhaoyan
    Liu, Qian
    Liang, Jingjia
    Gu, Aihua
    [J]. NUTRITION, 2021, 84
  • [9] Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults
    Fu, Xihang
    Li, Huiru
    Chen, Xinzhen
    Cai, Jinliang
    Yao, Ting
    Song, Lingling
    Cen, Manqiu
    Wu, Jing
    [J]. NUTRITIONAL NEUROSCIENCE, 2023, 26 (07) : 594 - 604
  • [10] Association of Demographic, Lifestyle, Physiologic, and Intake Variables With Urine Caffeine and Caffeine Metabolites in the US Population
    Rybak, Michael
    Pao, Ching-I
    Sternberg, Maya
    Ahluwalia, Namanjeet
    Pfeiffer, Christine
    [J]. FASEB JOURNAL, 2015, 29