Gerfelin, a novel inhibitor of Geranylgeranyl diphosphate synthase from Beauveria felina QN22047 -: I.: Taxonomy, fermentation, isolation, and biological activities

被引：34
|
作者：
Zenitani, S
Tashiro, S
Shindo, K
Nagai, K
Suzuki, K
Imoto, M [1 ]
机构：
[1] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Yokohama, Kanagawa 2238522, Japan
[2] Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan
[3] Yamanouchi Pharmaceut Co Ltd, Microbiol Labs, Inst Drug Discovery Res, Itabashi Ku, Tokyo 1748511, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 07期
关键词：
D O I：
10.7164/antibiotics.56.617
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.
引用
收藏
页码：617 / 621
页数：5
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