Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

被引：15
|
作者：
Andersen, Vibeke [1 ]
Christensen, Jane [2 ]
Overvad, Kim [4 ,5 ]
Tjonneland, Anne [2 ]
Vogel, Ulla [3 ,6 ]
机构：
[1] Viborg Reg Hosp, Dept Med, DK-8800 Viborg, Denmark
[2] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark
[3] Natl Res Ctr Working Environm, Copenhagen, Denmark
[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark
[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark
[6] Tech Univ Denmark, Natl Food Inst, Soborg, Denmark
来源：
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2011年 / 23卷 / 03期
关键词：
carcinogenesis; cohort; epidemiology; gene-environment interaction; population-based; prospective study; red and processed meat; PROSPECTIVE COHORT; HEART-DISEASE; RED MEAT; PROMOTER; ALCOHOL; GENE;
D O I：
10.1097/MEG.0b013e3283417f76
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objective Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis. Methods Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated. Results No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates = 0.29). No interaction with meat intake was found (P value for interaction = 0.55). Conclusion The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development. Eur J Gastroenterol Hepatol 23: 282-285 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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页码：282 / 285
页数：4
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